2. Signaling Pathways
  3. GPCR/G Protein
  4. Adenosine Receptor

Adenosine Receptor

P1 receptor

Adenosine Receptor

Related Products

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Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.

Adenosine Receptor Isoform Specific Products:

Adenosine Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-123127
    CVT-2759 analog
    		Agonist
    CVT-2759 analog (compound 15) is a partial agonist of A1 adenosine receptor (Ki=167 nM) and can be used for the study of cardiac arrhythmias.
    CVT-2759 analog
  • HY-134555
    A3AR antagonist 4
    		Antagonist
    A3AR antagonist 4 (Compd 1) is an A3AR antagonist, with Ki values of 30.8 nM (hA3) and 203 nM (hA1), repectively. A3AR antagonist 4 (Compd 1) can be used for the study of cerebral ischemia.
    A3AR antagonist 4
  • HY-111088
    LUF5981
    		Antagonist
    LUF5981 is a relatively potent adenosine A2A receptor (A2A) antagonist with pIC50 value of 6.7.
    LUF5981
  • HY-B0004R
    Doxofylline (Standard)
    		Antagonist
    Doxofylline (Standard) is the analytical standard of Doxofylline. This product is intended for research and analytical applications. Doxofylline is an orally active PDE IV inhibitor and A1AR antagonist. Doxofylline reduces inflammation in epithelial cells via inhibiting mitochondrial ROS production and amelioration of multiple cellular pathways (NLRP3-TXNIP inflammasome activation). Doxophylline can be used in studies of asthma, chronic obstructive pulmonary disease, and bronchospasm.
    Doxofylline (Standard)
  • HY-100678R
    CGS 15943 (Standard)
    		Antagonist
    CGS 15943 (Standard) is the analytical standard of CGS 15943. This product is intended for research and analytical applications. CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. .
    CGS 15943 (Standard)
  • HY-123038
    CVT-5440
    		Antagonist
    CVT-5440 is a xanthine based, selective, high affinity A2B adenosine receptors (AdoR) antagonist with a Ki of 50 nM (selectivity A1> 200; A2A>200; A3>167). CVT-5440 has the potential for asthma research.
    CVT-5440
  • HY-N0127R
    Yohimbine (Hydrochloride) (Standard)
    		Inhibitor
    Yohimbine Hydrochloride Standard is an alpha-2 renal adenomatase receptor inhibitor, blocking pre- and post-contact alpha-2 renal adenomatase receptors, causing the release of renal adenoma and multiple sclerosis.
    Yohimbine (Hydrochloride) (Standard)
  • HY-118086
    MRS1067
    		Antagonist
    MRS 1067 is a competitive antagonist of the adenosine A3 receptor that inhibits the suppression of adenylate cyclase by adenosine A3 receptor agonists and affects the activation of G proteins. MRS 1067 can be used in research related to inflammation and cancer.
    MRS1067
  • HY-101139AR
    Xanthine amine congener hydrochloride (Standard)
    		Antagonist
    Xanthine amine congener (hydrochloride) (Standard) is the analytical standard of Xanthine amine congener (hydrochloride). This product is intended for research and analytical applications. Xanthine amine congener (XAC) hydrochloride is a non-selective adenosine receptor antagonist. Xanthine amine congener hydrochloride induces convulsions in mice.
    Xanthine amine congener hydrochloride (Standard)
  • HY-171467
    MRS7799
    		Antagonist
    MRS7799 is a selective A 3 Adenosine Receptor antagonist agsinst human, mouse, and rat A3AR with Kds of 0.55, 3.74 and 2.80 nM, respectively. MRS7799 can be used in the study of neurodegeneration, cancer, ischemia of the heart and brain, autoimmune inflammatory diseases.
    MRS7799
  • HY-103182A
    PSB-1115 potassium salt
    		Antagonist
    PSB-1115 potassium salt is a selective A2B Adenosine Receptor antagonist. PSB-1115 potassium salt inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh).
    PSB-1115 potassium salt
  • HY-103167
    CGH2466 dihydrochloride
    		Antagonist
    CGH 2466 dihydrochloride is an orally active adenosine A1, A2B and A3 receptor antagonist with the IC50 values of 19 nM, 21 nM, and 80 nM respectively. CGH 2466 dihydrochloride inhibits p38 MAPK (IC50 = 187~ 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). CGH 2466 dihydrochloride displays potent anti-inflammatory effects both in vitro and in vivo, and can be used for research on asthma and chronic obstructive pulmonary disease (COPD).
    CGH2466 dihydrochloride
  • HY-111306
    ATL-802
    		Antagonist
    ATL-802 is a potent adenosine A2B receptor antagonist. ATL-802 is promising for research of diabetes.
    ATL-802
  • HY-103171R
    BAY 60-6583 (Standard)
    		Agonist
    BAY 60-6583 (Standard) is the analytical standard of BAY 60-6583. This product is intended for research and analytical applications. BAY 60-6583 is a potent and high-affinity agonist of adenosine A2B receptor (EC50?= 3 nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with Ki values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model.
    BAY 60-6583 (Standard)
  • HY-103188
    PD81723
    		Activator
    PD81723 is an adenosine receptor binding enhancer. PD81723 enhances the inhibition of exogenous adenosine in a dose-dependent manner in hippocampal brain sections.
    PD81723
  • HY-162851
    Adenosine receptor agonist 1
    		Agonist
    Adenosine receptor agonist 1 (compound 6m) is an A3 adenosine receptor (AR) partial agonist with Ki value of 6.7 nM.
    Adenosine receptor agonist 1
  • HY-W017163R
    7-Methylxanthine (Standard)
    		Antagonist
    7-Methylxanthine (Standard) is the analytical standard of 7-Methylxanthine. This product is intended for research and analytical applications. 7-Methylxanthine is an orally active methyl derivative of xanthine and a non-selective adenosine receptor antagonist. 7-Methylxanthine is also one of the purine components of human urinary calculi. 7-Methylxanthine has anti-myopia activity.
    7-Methylxanthine (Standard)
  • HY-B0140R
    Aminophylline (Standard)
    		Antagonist
    Aminophylline (Standard) is the analytical standard of Aminophylline. This product is intended for research and analytical applications. Aminophylline is a competitive and non-selective phosphodiesterase (PDE) inhibitor. Aminophylline is a competitive adenosine receptor antagonist. Aminophylline has apulmonary vasodilator action as well as a bronchodilator action and has the potential for asthma research.
    Aminophylline (Standard)
  • HY-B0128R
    Diphylline (Standard)
    		Antagonist
    Diphylline (Standard) is the analytical standard of Diphylline. This product is intended for research and analytical applications. Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator agent and has the potential for chronic bronchitis and emphysema.
    Diphylline (Standard)
  • HY-111129
    CP-66713
    		Antagonist
    CP-66713 is a selective adenosine A2 receptor antagonist, with Ki of 22 nM. CP-66713 inhibits induction of long-term potentiation of evoked synaptic potentials. CP-66713 can be used in the study of neurological diseases.
    CP-66713
Cat. No. Product Name / Synonyms Application Reactivity
Adenosine Receptor Isoform Comparison

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